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Banaba (Lagerstroemia speciosa)
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Banaba/Drug Interactions:- AntibioticsAntibiotics: In vitro, Lagerstroemia speciosa seed extract showed antibacterial activity against various Gram-positive and Gram-negative bacteria (21).
- AntidiabeticsAntidiabetics: Banaba has lowered blood glucose in both animal and human studies (2; 17), and studies in vitro suggest that constituents of banaba may have insulin-like effects (22) or activate insulin receptors (23). In vitro, an extract of Lagerstroemia speciosa L. exerted insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activity in 3T3-L1 cells (24). According to animal data, the Lythraceae family may increase the rate of glucose uptake and decrease the isoproterenol-induced glycerol release (23).
- AntifungalsAntifungals: In vitro, extracts from Lagerstroemia speciosa demonstrated strong antifungal activity against Arthrinium sacchari and Chaetomium funicola (3).
- Antigout agentsAntigout agents: In in vitro research, valoneic acid, a constituent of banaba, has demonstrated xanthine oxidase-inhibiting activity (7).
- AntihypertensivesAntihypertensives: In an animal model of metabolic syndrome, male SHR-cp rats were fed a high-fat diet containing 0.072% corosolic acid for 14 weeks, which lowered blood pressure and serum free fatty acids (18).
- Anti-inflammatoriesAnti-inflammatories: Lagerstroemia speciosa has not been observed to affect Pseudomonas aeruginosa-dependent interleukin (IL)-8 mRNA induction in bronchial epithelial cells in vitro (25). In carrageenan-induced acute inflammation and formalin-induced (chronic) paw edema models, an ethyl acetate extract of Lagerstroemia speciosa L. reduced the paw edema significantly in a dose-dependent manner, whereas ethanol extract did not show dose-dependent activity (26).
- AntilipemicsAntilipemics: In KK-Ay diabetic mice fed a high-fat diet (an animal model of type 2 diabetes), corosolic acid inhibited mean blood cholesterol levels (27).
- AntineoplasticsAntineoplastics: In vitro, low concentrations of extracts from Lagerstroemia speciosa inhibited interactions between nuclear factors and target DNA elements mimicking sequences recognized by the nuclear factor-kappaB (NF-kappaB) (28). In vitro, extracts of Lagerstroemia speciosa inhibited cell proliferation in human tumor cell lines, including human erythromyeloid K562 (29).
- Antiobesity agentsAntiobesity agents: In studies in obese mice, banaba appeared to control weight gain (13); however, this effect has not been studied in humans.
- Antiviral agentsAntiviral agents: In vitro, orobol 7-O-D-glucoside from banaba induced a cytotoxic effect on human rhinovirus (HRV) as evidenced by a 50% cytotoxicity concentration (CC50) of more than 100mcg/mL, and the derived therapeutic indices of more than 12 (5).
- Dopamine agonistsDopamine agonists: In in vitro research, the sulfation of dopamine was inhibited by extracts of banaba (30).
- Drugs used for osteoporosisDrugs used for osteoporosis: In vitro, corosolic acid (2alpha-hydroxyursolic acid), an active component of banaba leaves, induced NF-kappaB and MAP kinase activity at an early stage of osteoblast differentiation and increased the activity of the transcription factor AP-1 during late-stage osteoblast differentiation (10).
- Organic anion-transporting polypeptide B substratesOrganic anion-transporting polypeptide B substrates: In in vitro research, extract of banaba, at concentrations likely attainable in the human intestine, inhibited estrone-3-sulfate uptake (31).
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Banaba/Herb/Supplement Interactions:- AntibacterialsAntibacterials: In vitro, Lagerstroemia speciosa seed extract showed antibacterial activity against various Gram-positive and Gram-negative bacteria (21).
- AntifungalsAntifungals: In vitro, extracts from Lagerstroemia speciosa demonstrated strong antifungal activity against Arthrinium sacchari and Chaetomium funicola (3).
- Antigout agentsAntigout agents: In in vitro research, valoneic acid, a constituent of banaba, has been demonstrated to possess xanthine oxidase-inhibiting activity (7).
- Anti-inflammatoriesAnti-inflammatories: Lagerstroemia speciosa has not been observed to affect Pseudomonas aeruginosa-dependent interleukin (IL)-8 mRNA induction in bronchial epithelial cells in vitro (25). In carrageenan-induced acute inflammation and formalin-induced (chronic) paw edema models, an ethyl acetate extract of Lagerstroemia speciosa L. reduced the paw edema significantly in a dose-dependent manner, whereas ethanol extract did not show dose-dependent activity (26).
- AntilipemicsAntilipemics: In KK-Ay diabetic mice fed a high-fat diet (an animal model of type 2 diabetes), corosolic acid inhibited mean blood cholesterol levels (27).
- Antiobesity agentsAntiobesity agents: In studies in obese mice, banaba appeared to control weight gain (13); however, this effect has not been studied in humans.
- AntioxidantsAntioxidants: Extracts of Lagerstroemia speciosa have demonstrated antioxidant effects in vitro (32; 26). In an animal model of metabolic syndrome, male SHR-cp rats were fed a high-fat diet containing 0.072% corosolic acid for 14 weeks, which decreased the levels of oxidative stress markers, thiobarbituric acid-reactive substances, and 8-hydroxydeoxyguanosine (18).
- AntineoplasticsAntineoplastics: In vitro, low concentrations of extracts from Lagerstroemia speciosa inhibited interactions between nuclear factors and target DNA elements mimicking sequences recognized by the nuclear factor-kappaB (NF-kappaB) (28). In vitro, extracts of Lagerstroemia speciosa inhibited cell proliferation in human tumor cell lines, including human erythromyeloid K562 (29).
- AntiviralsAntivirals: In vitro, orobol 7-O-D-glucoside from banaba induced a cytotoxic effect on human rhinovirus (HRV) as evidenced by a 50% cytotoxicity concentration (CC50) of more than 100mcg/mL, and the derived therapeutic indices of more than 12 (5).
- Dopamine agonistsDopamine agonists: In in vitro research, the sulfation of dopamine was inhibited by extracts of banaba (30).
- HypoglycemicsHypoglycemics: Banaba has lowered blood glucose in both animal and human studies (2; 17), and studies in vitro suggest that constituents of banaba may have insulin-like effects (22) or activate insulin receptors (23). In vitro, an extract of Lagerstroemia speciosa L. exerted insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activity in 3T3-L1 cells (24). According to animal data, the Lythraceae family may increase the rate of glucose uptake and decrease the isoproterenol-induced glycerol release (23).
- HypotensivesHypotensives: In an animal model of metabolic syndrome, male SHR-cp rats were fed a high-fat diet containing 0.072% corosolic acid for 14 weeks, which lowered blood pressure and serum free fatty acids (18).
- Organic anion-transporting polypeptide B substratesOrganic anion-transporting polypeptide B substrates: In in vitro research, extract of banaba, at concentrations likely attainable in the human intestine, inhibited estrone-3-sulfate uptake (31).
- Osteoporosis agentsOsteoporosis agents: In vitro, corosolic acid (2alpha-hydroxyursolic acid), an active component of banaba leaves, induced NF-kappaB and MAP kinase activity at an early stage of osteoblast differentiation and increased the activity of the transcription factor AP-1 during late-stage osteoblast differentiation (10).
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Banaba/Food Interactions:- GeneralGeneral: Banaba may influence glucose absorption from food (33).
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Banaba/Lab Interactions:- Blood glucoseBlood glucose: Banaba may lead to lower blood glucose levels (2).
- Blood pressureBlood pressure: In an animal model of metabolic syndrome, male SHR-cp rats were fed a high-fat diet containing 0.072% corosolic acid for 14 weeks, which lowered blood pressure (18).
- Body weightBody weight: According to studies in obese mice, banaba appeared to control weight gain (13); however, this effect has not been studied in humans.
- Hemoglobin A1cHemoglobin A1c: In db/db mice (a typical non-insulin-dependent model) fed a diet of 0.5% banaba leaf water extract diet or a 0.5% combination diet of mulberry leaf water extract, Korean red ginseng, and banaba leaf water extract (1:1:1), hemoglobin (HbA1c) was reduced (34).
- InsulinInsulin: In KK-Ay mice fed a high-fat diet, corosolic acid treatment reduced fasting plasma insulin (4).
- Lipid profileLipid profile: In KK-Ay diabetic mice fed a high-fat diet (an animal model of type 2 diabetes), corosolic acid inhibited mean blood cholesterol levels and reduced fasting plasma triglyceride levels (27). One lab study found that banaba may lower triglycerides (13).
- Renal function testsRenal function tests: An ethyl acetate extract of Lagerstroemia speciosa L. ameliorated cisplatin-induced nephrotoxicity in mice, as measured by urea and creatinine concentrations (9).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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